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Beyond its addictive properties, short-term or long-term exposure to nicotine in adults has not been established as dangerous "Electronic Cigarettes: Vulnerability of Youth"

Latent class analysis was used to classify the participants into five groups based on their tobacco and cannabis use over time

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In response to these challenges identified with the self-medication hypothesis, researchers have developed an alternate theory to explain the heightened prevalence of smoking in SZ which is termed the addiction vulnerability hypothesis (43)